摘要 |
Compounds (I) and (II), including enantiomers, racemates and acid addition and quaternary salts, are for treating diseases of the central and peripheral nervous system, (see formula I and II) wherein in formula (I) Q is (CH2)m or C(CH3)2 attached to the 1',4' or 1',5' positions of the six-membered ring (m = 1, 2 or 3.) and in formula (II) Q is two hydrogen atoms, (CH2)m or C(CH3)2 (m = 1, 2 or 3) and n and p are each independently 0, 1, 2 or 3, provided that n + p = 2-3; R.degree. is hydrogen, methyl or OH; (see formula III) is (see formula IV), (see formula V), (see formula VI or VII) R and R' are independently H, NH2, NH-C1-6-alkyl, N(C1-6-alkyl)2, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-7- cycloalkyl, C1-6- alkyl substituted by 1-6 halogen atoms, HO- C1-6-alkyl, C1-6- alkoxy, C1-6-alkylthio, C1-6-alkoxy-C1-6-alkyl, carboxy-C1-6- alkyl, (C1-6-alkoxy)carbonyl-C1-6-alkyl, amino-C1-6-alkyl, mono- (C1-6-alkyl)amino-C1-6-alkyl, di-(C1-6-alkyl)amino-C1-6-alkyl, 2- oxo-pyrrolidin-1-yl-methyl, Ar, di(Ar)methylol, or (Ar)1-2C1-6 alkyl, or R' may be C1-6-alkanoyl or Arcarbonyl; and Ar denotes Ph optionally substituted by 1-3 of halogen, C1-6-alkyl, C1-6- alkoxy and GF3, subject to certain provisos.
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申请人 |
FISHER, ABRAHAM;SEGALL, YOFFI;SHIRIN, EZRA;KARTON, YISHAI;MESHULAM, HAIM |
发明人 |
FISHER, ABRAHAM;SEGALL, YOFFI;SHIRIN, EZRA;KARTON, YISHAI;MESHULAM, HAIM |