ENHANCEMENT OF THE DOWN-REGULATION OF AUTOIMMUNE DISEASES BY ORAL ADMINISTRATION OF AUTOANTIGENS

摘要

2077340 9112816 PCTABS00007 Disclosed herein are methods to prevent or treat T-cell dependent autoimmune diseases comprising the oral administration of (A) an agent selected from the group consisting of autoantigens, fragments or analogs thereof specific for the autoimmune disease, and (B) a synergist having the property of enhancing the autoimmune disease suppressive activity of the agent, in amounts effective to treat or prevent a T-cell dependent autoimmune disease. Also disclosed are pharmaceutical formulations or dosage forms for use in the methods.