SYNTHETIC PEPTIDES FOR NEUTRALIZING THE INFECTIVITY OF THE AIDS VIRUS (HIV)

摘要

There is disclosed a new peptide corresponding to the sequence of amino acids FYIFFVEDQKEEDD or to its variants X1YIX2X3VEDQKX4X5DD (X1=T or F, X2=C or F, X3=E or F, X4=E or F, X5=E or F) with activity in vitro against the infection by HIV which allows the micromolar 164 concentration to inhibit up to 95 % the capacity of HIV to form giant cells (syncytes) with Mol-3 cells and to inhibit 75 % of its capacity to synthesize the protein p17 of the core. These peptides have therapeutic potential not only in individuals infected with AIDS but also with AIDS-related diseases. Said peptides could also be useful in the profusion of the disease or to revert it in seropositive asymptomatic individuals. Furthermore, said peptides may be efficient for the prevention of the infection in high risk individuals, with possible exposure to HIV and in infants born from seropositive mothers. Its synthesis, after selecting the most appropriate sequence, is carried out by the method of Marriefield in modified solid phase or by genetic engineering.