发明名称 |
5-OXYGENATED-2,4,6-TRIAMINOPYRIMIDINES |
摘要 |
The present invention discloses 5-oxygenated amino substituted pyrimidines (X), where R1 is (1) steroid substituent of formula (Steroid), (2) trolox substituent of formula (trolox), (3) an alkyl substituent selected from the group consisting of (A)Q2-(CH2)n2. Also disclosed are the oxygenated N,N-disubstituted pyrimidines (XIII) all of which are useful for treating a number of conditions including head injury, stroke, spinal cord injury, etc. Useful intermediates including the protected 5-oxygenated pyrimidines (VII) and the 5-oxygenated pyrimidines (VIII) are also disclosed. Further disclosed are 5-hydroxy amino substituted pyrimidines (XI). |
申请公布号 |
WO9111453(A2) |
申请公布日期 |
1991.08.08 |
申请号 |
WO1991US00017 |
申请日期 |
1991.01.08 |
申请人 |
THE UPJOHN COMPANY |
发明人 |
MCCALL, JOHN, MICHAEL;JACOBSEN, ERIC, JON |
分类号 |
A61K31/505;A61K31/57;A61P3/06;A61P43/00;C07D239/50;C07D403/12;C07D405/12;C07J43/00 |
主分类号 |
A61K31/505 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|