SOLUBLE T-CELL ANTIGEN RECEPTOR CHIMERIC ANTIGENS

摘要

Soluble antigens useful for efficient production of antibodies against human T-cell receptor epitopes are provided. A preferred antigen is a chimeric polypeptide comprising at least 100 amino acids from a V beta domain with solubility conferred by an immunoglobulin heavy chain CH2 or CH3 domain fused thereto. Product antibodies and methods for diagnostic and therapeutic uses for both antigens and antibodies are provided.