| 摘要 |
There are disclosed compounds of the formula <IMAGE> wherein R1 and R2 are each, independently, hydrogen, alkyl, or phenyl, or R1 and R2 taken together represent -(CH2)4- or <IMAGE> where the dotted line represents an optional double bond; R3 is hydrogen, alkyl, alkoxy, or halo; Z is oxygen, or -N(R6), where R6 is hydrogen or alkyl; m is 1-4; n is 0-2; <IMAGE> <IMAGE> wherein R7 is unsubstituted or substituted phenyl, 2-pyridinyl, 2-pyrimidinyl, 2-pyrazinyl, 3-pyridazinyl, or diphenylmethyl, where the substituents are selected from the group of alkyl, alkoxy, halo, cyano, nitro and trifluoromethyl; R8 is hydrogen, hydroxy, cyano, alkyl, alkoxy, halo, or NHR9 where R9 is hydrogen, alkyl, phenyl, tolyl, xylyl, mesityl, methoxyphenyl, or halophenyl with the proviso when Z is oxygen, R7 is other than phenyl or pyridyl; or a pharmaceutically acceptable salt thereof, which by virtue of high affinity for the dopamine D-2 receptor and the serotonin 5-HT-1A receptor, are useful as antipsychotic and anxiolytic agents for the treatment of a variety of central nervous system disorders such as paranoia, schizophrenia, anxiety, sleep disorders, and related problems.
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