| 摘要 |
Basic fibroblast growth factor, a 146 amino acid residue polypeptide, analogs thereof, a lectin, suramin, protamine and/or a shortened fragment of either bFGF or of an analog thereof is used to prevent the spread of HSV-1. It has been found that topical application of an effective amount of such an agent prevents HSV uptake and/or infection in cells that are otherwise targets for such virus. One group of preferred agents are peptides which include the decapeptide sequence of a mammalian bFGF(106-115), e.g., bovine bFGF(106-115), examples of such preferred peptides include bovine bFGF(103-120)-NH2 and human bFGF(103-120)-NH2. |
