| 摘要 |
The present invention relates to a method for the preparation of beta -hydroxyketones represented by general formula (I), (where R is an alkyl group which may have a methyl group at the alpha position, an alkyl group substituted by alkylthio group which may have a methyl group at the alpha position, an alicyclic group which may have substituents at positions other than the alpha , beta and beta ' positions, a heterocyclic group which may have substituents at positions other than the alpha , beta and beta ' positions, and phenyl group which may have an electron withdrawing group at the para position), by reacting aldehydes represented by formula (A): RCHO (where R is as defined above) with aqueous solution of alkali metal salt of acetoacetic acid represented by formula (B) (where M<+> is an alkali metal ion), a method for the preparation of the said beta -hydroxyketones which comprises reacting (A) and (B) when a mole ratio of (A) to (B) is 1.0 to 1.5 if (A) has two hydrogen atoms, 1.5 to 2.0 if one hydrogen atom, 2.0 to 2.5 if no hydrogen atoms and 1.1 to 1.5 if R is a phenyl group with electron withdrawing group at the para position even if no hydrogen atoms, at a pH of 9 to 10. |
