摘要 |
There are disclosed compounds of the formula <IMAGE> wherein R is hydroxy, lower alkoxy or lower alkoxyamino; R1 is hydrogen or A(CH2)nO-; R2 is hydrogen or A(CH2)nO-, with the proviso that one of R1 and R2 is A(CH2)nO- and the other is hydrogen; n is 1-2; A is phenoxyethyl, phenoxyphenyl or a group having the formula <IMAGE> X is -N- or <IMAGE> Z is <IMAGE> R3 is hydrogen, lower alkyl or phenyl; R4 is hydrogen or lower alkyl; or R3 and R4 taken together form a benzene ring; R5 is hydrogen or lower alkyl; R6 is hydrogen, halo or lower alkyl; and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents. |