PROCESS FOR PRODUCING 2-CARBON-SUBSTITUTED CARBAPENEM DERIVATIVES

摘要

A process for producing a 2-(unsubstituted or carbonsubstituted)-1-carbapen-2-em-3-carboxylic acid derivative, which comprises reacting a 2trifluoromethanesulfonyloxy-1-carbapen-2-em-3-carboxylic acid derivative or the 1-carbapen-2-em-3-carboxylie acid derivative derived from a 2-oxo-1-carbapenam-3-carboxylic aeid derivative and trifluoromethanesulfonic anhydride, and a stannane derivative in an inert solvent in the presence of a palladium compound and a salt.