发明名称 |
Novel immunoconjugates and methods for their use in tumor therapy. |
摘要 |
<p>Novel pH-sensitive immunoconjugates which dissociate in low-pH tumor tissue, comprising a chemotherapeutic agent and an antibody reactive with a tumor-associated antigen are described. The chemotherapeutic agent is coupled to the antibody by a link which is unstable in low pH. The link may comprise a spacer consisting of a polyamino acid. Representative antibodies for use in these immunoconjugates include monoclonal antibodies which are not internalized by tumor cells.</p> |
申请公布号 |
EP0428188(A2) |
申请公布日期 |
1991.05.22 |
申请号 |
EP19900125137 |
申请日期 |
1987.06.30 |
申请人 |
ONCOGEN |
发明人 |
HELLSTROM, KARL ERIK;HELLSTROM, INGEGERD E.;LAVIE, EFRAIM |
分类号 |
A61K39/395;A61K45/08;A61K47/48;A61P35/00;C07K1/113;C07K14/00;C07K14/76;C07K16/00;C07K19/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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