The invention provides pyrimidoisoquinoline derivatives having the general formula:
<CHEM>
wherein
R<1> hydrogen, halogen or lower alkyl,
R<2> is amino, nitro or acylamino and
R<3> is carboxy or protected carboxy and pharmaceuticaliy acceptable salts thereof.
<??>These compounds possess useful antiallergic properties and are effective in the treatment of symptoms associated with allergic diseases.
<??>The invention further relates to processes for the preparation of these compounds and pharmaceutical compositions comprising compounds of the above formula.
