3-Substituted-2-oxindole derivatives as inhibitors of interleukin-1 biosynthesis.

摘要

This invention relates to the use of certain 3-substituted-2-oxindole derivatives for the manufacture of a medicament for inhibiting interleukin-1 biosynthesis in a mammal. This invention also relates to the use of such compounds for the manufacture of medicaments for treating interleukin-1 mediated disorders and dysfunctions such as bone and connective tissue metabolism disorders and immune dysfunction in a mammal.