| 摘要 |
PURPOSE:To obtain a calcium metabolism improver having stability even in a solution state and especially improved absorption per rectum free from side effects, comprising a polypeptide derivative having specific structure and protease inhibitor and/or acid as active ingredients. CONSTITUTION:A calcium metabolism improver comprising (A) a polypeptide shown by the formula (A is alkylene or phenylene; B is NHCO, S, etc.; D is alkylene; E is Ser, beta-Ala, etc.; F is Val, Gly, etc.; G is Lys, Gly, etc.; H is His, Asp, etc.; I is Lys, Asn, etc.; J is Tyr, Leu, etc.; E is Arg, Gln, etc.; (l), (m), (n), (p), (q), (r), (s) and (t) are 0 or 1), an acid addition salt or a complex thereof, (B) a protease inhibitor such as chymostatin or aprotinin and/or (C) a pharmaceutically acceptable acid, preferably solid organic acid in the ratio of 1,500-3X10<5> pts.wt. component B based on 1 pt.wt. component A and 5,000-2X10<5> pts.wt. component C based on 1 pt.wt. component A. |
