| 摘要 |
<p>Novel pharmaceutically active bisphosphonic acid derivatives of formula (I), in which R?1, R2, R3 and R4¿ independently are C¿1?-C22-alkyl, C2-C22-alkenyl, C2-C22-alkynyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl, aryl, aralkyl, silyl or hydrogen, whereby in the formula (I) at least one of the groups R?1, R2, R3 and R4¿ is hydrogen and at least one of the groups R?1, R2, R3 and R4¿ is different from hydrogen, Q1 is hydrogen, fluorine, chlorine, bromine or iodine, and Q2 is chlorine, bromine or iodine, including the stereoisomers, such as the geometrical isomers and optically active isomers, of the compounds, as well as the pharmaceutically acceptable salts of the compounds.</p> |
