NEW VITAMIN B12 DERIVATIVE, PRODUCTION AND USE THEREOF

摘要

NEW MATERIAL:A compound expressed by formula I [L is ligand of choline ring to cobalt; B is base having heterocyclic structure; R is (substituted) hydrocarbon]. EXAMPLE:2-(5,6-dimethylbenzimidazolyl) ethylcyanochobinamide phosphate. USE:Suppressing and inhibiting agent against cell propagation, or antitumor agent. PREPARATION:Cyanoaquachobinamide or dicyanochobinamide is subjected to condensation reaction with phosphate derivative expressed by formula II or salt of said derivative to obtain the aimed compound.