NOVEL OLIGODEOXYNUCLEOTIDES WITH 5'-LINKED CHEMICAL GROUPS, METHOD OF PRODUCTION THEREOF AND USE THEREOF

摘要

Method of synthesis is provided for novel oligodeoxynucleotides 5' linked to covalently attached chemical groups via intermediate linked phosphoramidites. The synthesis of the covalently attached chemical group to a phosphoramidite moiety occurs outside the automatic synthesizer, followed by application of this complex as a terminator of the 5' end of a phosphate-modified oligodeoxynucleotide in the automatic synthesizer. The compounds are used to attenuate or destroy mammalian gene expression or viral activity.