| 摘要 |
Disclosed is a novel peptide having one of the formulae: <CHEM> (A and B are the amino acids: wherein if A is D- or L-Pro, B is Har or Cit; if A is D-Pro, B is D-Arg, and if B is D- or L-Arg, A is Sar, Pip, Aze or Arg) Asn-A-L-(D-)Pro-Arg-(Gly)n (A is Ser, Thr or Ala, n is 1 or 0) A-Ser-Pip-Arg (A is Pro-Asn-, Asn- or Pro-) A- @ys-Pro-Arg-B (A is cyclopentylcarbonyl, Pro or pGlu; B is Gly or beta -Ala, W is a hydrogen atom or a group having the formula: H- @ys-OH) or a peptide having the formula: (A- @ys-Pro-Arg-B)2 wherein A and B have the same meanings as mentioned above, respectively pGlu-Asn-Ser-A-B-(Gly)n (A is Aze, D- or L-Pro, Pip or Sar, B is D- or L-Arg, Cit, Har, Lys or Orn, n is 1 or 0) and Pro-(Asn)m-Ser-L-(D-)Pro-Arg-(Gly)n (m and n are independently 0 or 1) their functional derivatives, and pharmaceutically acceptable salts thereof. |
