GRANULATES FOR MULTIPARTICULATE CONTROLLED-RELEASE ORAL COMPOSITIONS

摘要

Granulates for multiparticulate controlled-release oral compositions comprising biologically active substances in solid dispersion with an acid-resistance and/or release-limiting compound, the solid dispersion being mixed with water-insoluble carrier particles, and the preparation of such granulates. Preferred biologically active substances are corticosteroids, non-steroidal anti-inflammatory drugs and bismuth compounds. The granules have a preferred particle size of less than 1 mm.