| 摘要 |
NEW MATERIAL:A compound shown by formula I [X is D-Ala, D-Met(O) or D-Arg; Y is Phe, Phe(NO2) or MePhe; Z is group shown by formula II, Leu-NH- CH2 or NH-CH2]. EXAMPLE:A compound shown by formula III. USE:Having opioid activity, manifesting morphine-like analgesic action irrespective of dosage form and useful as an analgesic. PREPARATION:A compound shown by formula IV is dissolved in methanol, mixed with (n-Bu)3P while stirring, further with a solution of Npys-Cl in dioxane at 0 deg.C and reacted at room temperature and powder is obtained from the filtrate and recrystallized to give the aimed compound. |
