TYPE A PLATELET-DERIVED GROWTH FACTOR RECEPTOR GENE

摘要

Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used successfully to pro- duce a hitherto unknown type of human Platelet-Derived Growth Factor (PDGF) receptor protein (see genetic map, figure 2) free of other PDGF receptors. These proteins can be produced from DNA segments in cells in various functional forms. These forms variously enable biochemical and functional studies of these novel receptors as well as production of antibodies. Means are de- scribed for determining the level of expression of genes for specific types of PDGF receptor proteins, for example, by measuring mRNA in cell with PDGF receptor type-specific DNA probes or by measuring antigene in biological samples with type-specific antibodies.