发明名称 |
KOGAKUKATSUSEI11CHIKANN22AMINOPUROPANNOSEIHO |
摘要 |
PURPOSE:To obtain the titled compound useful as a synthetic intermediate for various pharmaceuticals, either by reducing an optically active 3- substituted-2-aminopropanol derivative in the presence of a metal halide or by reacting said compound with a metal halide and reducing the reaction product. CONSTITUTION:The objective compound of formula III can be produced either by (1) reacting a compound of formula I [R<1> is (substituted) aryl or nitrogen- containing heterocyclic group; OZ is protected OH; -NHY is (protected) amino] or its salt with a reducing agent (e.g. metallic zinc) in the presence of a metal halide (e.g. sodium iodide) at 20-100 deg.C or by (2) reacting the compound of formula I or its salt with a metal halide in a mixed solvent of water and THF, etc., at 120-100 deg.C and reducing the resultant corresponding propyl halide of formula II (X is halogen). EFFECT:The objective compound can be produced from an easily available raw material in high purity and yield. |
申请公布号 |
JPH0229071(B2) |
申请公布日期 |
1990.06.27 |
申请号 |
JP19860084493 |
申请日期 |
1986.04.11 |
申请人 |
TANABE SEIYAKU CO |
发明人 |
YAMADA KOICHIRO;IWAKUMA TAKEO |
分类号 |
C07B61/00;B01J27/00;B01J27/10;B01J31/00;B01J31/02;C07C209/74;C07C211/27;C07C211/29;C07C213/02;C07C213/08;C07C215/46;C07C217/60;C07C231/12;C07C233/02;C07C233/17;C07C271/10;C07C271/48;C07C317/32;C07D209/14;C07D233/64 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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