| 摘要 |
NEW MATERIAL:A sangenone having physical and chemical properties as follows (sangenone D): description: yellow powder, molecular weight: 708 (according to the field desorption mass spectrography), melting point: 175-185 deg.C (decomposed), [alpha]D<25>=-145 deg. (c=0.173 in methanol); positive to ferric chloride reaction and to hydrochloric acid-magnesium reaction, hard soluble in water, hexane, chloroform, soluble in ethyl ether or ethyl acetate, easy soluble in methanol, ethanol, DMF, acetone; acidic substance. USE:Hypotensor with low toxicity. PREPARATION:For example, barks of mulberry tree roots are finely cut, defatted with a low-polarity organic solvent, then extracted with a lower alcohol. The extract is filtered, the filtrate is dried under reduced pressure to obtain an extract. The extract is subjected to column chromatography to separate impurities and collect fractions containing sangenone D. Then, sangenone is isolated and purified. |
