| 摘要 |
<p>Stable, concentrated, non-aqueous solutions of doxorubicin are provided containing a physiologically acceptable salt of doxorubicin and about 0.1 to 20 mg/ml of the antioxidant, sodium acetone bisulfite, in a solvent medium consisting of propylene glycol, 1,2-dihydroxybutane or 1,3-dihydroxypropane or mixtures of such non-aqueous solvents with water and, if required, an amount of a physiologically acceptable acid or base necessary to adjust the solution pH to within the range of about 3-6. The solutions have an acceptable shelf-life of greater than 18 months at room temperature and can be diluted with water or other aqueous parenteral vehicles for parenteral administration.</p> |
