发明名称 ALPHA-INTERFERON AND TREATMENT COMPOSITION CONTAINING SAID ALPHA-INTERFERON
摘要 PURPOSE: To obtain a composition comprising an α-interferon obtained by a genetic recombination technique and containing no protein originating from man and useful for treating viruses, human cancers or tumors and bovine viral infectious diseases. CONSTITUTION: This α-interferon is obtained by culturing a host transformed with a recombined DNA molecule comprising a DNA sequence selected from the group consisting of (A) a DNA insertion of Z-pBR322 (Pst)/HcIF-2h [DSM 1700], Z-pBR322 (Pst)/HcIF-SN-35 [DSM 1701], Z-pBR322 (Pst)/HcIF-SN 42 [DSM 1702] and Z-pKT 287 (Pst)/HcIF-2h-AH6 [DSM 1703], (B) a DNA sequence coding for a polypeptide having an antiviral activity and obtained by hybridizing the component A under specific conditions, and (C) a DNA sequence in which one or more codons are exchanged with synonymous codons coding for the same amino acids as those for which the DNA insertion and the sequence specified in the components A and B code.
申请公布号 JPH02131431(A) 申请公布日期 1990.05.21
申请号 JP19880307943 申请日期 1988.12.07
申请人 BIOGEN NV 发明人 CHIYAARUZU BAISUMAN
分类号 C12N15/09;A61K38/00;A61K38/21;A61P31/12;A61P35/00;A61P43/00;C07K14/00;C07K14/52;C07K14/555;C07K14/56;C12N1/00;C12N1/20;C12N15/00;C12N15/21;C12N15/70;C12P21/00;C12P21/02;C12R1/19 主分类号 C12N15/09
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