| 摘要 |
Aryloxy- and heteroaryloxy-alkylene derivatives of amines of formula <CHEM> wherein each of A and B is a group of formula (i) to (iii): <CHEM> wherein Y is -O-, -S- or -NR- in which R is hydrogen or C1-C6 alkyl; each of R3, R4, R5 and R6 is independently: a) hydrogen, halogen, hydroxy, cyano or nitro; b) C1-C6 alkyl unsubstituted or substituted by halogen, c) C1-C6 alkoxy or C1-C6 alkylthio; d) C1-C6 alkyl-sulfonyl; e) a substituted amine group -NR7R8; f) a -COR12 group; or g) two adjacent groups of R3, R4, R5 and R6, taken together, form a C1-C4 alkylenedioxy group; each of R1 and R2 independently is hydrogen, C3-C6 alkynyl, C3-C6 alkenyl or C1-C6 alkyl unsubstituted or substituted by phenyl; or R1 and R2 taken together with the nitrogen atom to which they are linked, form a substituted or unsubstituted, saturated heterocyclic ring; and the pharmaceutically acceptable salts thereof; are active on the central nervous nervous system, in particular as antidepresssant, antiobesity antismoking and anti-alcoholabuse agents. |
