| 摘要 |
<p>BENZOTHIAZINE DIOXIDE DERIVATIVES Certain novel 2-acetoxybenzoyl and ringsubstituted? -arylpropionyl derivatives of 4-hydroxy-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide and several other closelyrelated known oxicams have been prepared. These particular comounds are useful in therapy as nonsteroidal anti-arthritic agents. Typical member compounds include 4-(2-acetoxybenzoyloxy)-2-methyl-N- (2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1dioxide, 4-¢? -(4-isobutylphenyl)propionyloxy!-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, 4-¢?-(3-benzoylphenyl)propionyloxy!-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, d-4-¢?-(6-methoxynaphth-2-yl)-propionyloxy!-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, 2-methyl-4-¢? -(3-phonoxyphenyl)propionyloxy!-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide and 4-?- (2-fluoro-4-biphenylyl)propionyloxy!-2-methyl-N-(2-pyri-dinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide. Methods for preparing these compounds from known starting materials are provided.</p> |
