发明名称 Process for the detection of cancer
摘要 A technique and an apparatus are disclosed for the detection of cancer using nuclear magnetic resonance (NMR). Specifically, NMR parameters for protons of lipid methyl and/or methylene groups are determined and compared against a corresponding value for healthy patients. In the preferred embodiments, an NMR spectrometer is employed to provide a spectrum for non-water components of blood, blood serum or blood plasma and the width of the methyl and/or methylene groups is measured at half-height as a determination of spin-spin relaxation time (T2) which is the parameter used for purposes of comparison with healthy controls. Suppression of the water proton signal is employed where necessary in order to obtain a suitable spectrum for the non-water component protons. In the event that a positive reading is obtained, the level of plasma triglycerides is determined and if it is high, the patient's bodily fluid sample is further subjected to C-13 nuclear magnetic spectroscopy. The resonance line of the plasma C-13 spectra discriminates between true and false positive results from the proton NMR reading and determines the presence or absence of cancer in the patient.
申请公布号 US4918021(A) 申请公布日期 1990.04.17
申请号 US19890295746 申请日期 1989.01.10
申请人 THE BETH ISRAEL HOSPITAL ASSOCIATION 发明人 FOSSEL, ERIC T.
分类号 G01R33/465;G01R33/56 主分类号 G01R33/465
代理机构 代理人
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