| 发明名称 |
Process for the preparation of intermediates for the synthesis of diltiazem. |
| 摘要 |
Compound of formula III, which is an intermediate in the synthesis of diltiazem, is prepared by N-alkylation of the corresponding N-H derivative with 2-dimethylaminoethanol in an inert solvant and in presence of methanesulphonyl chloride and a base. <CHEM> e
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| 申请公布号 |
EP0355395(A1) |
申请公布日期 |
1990.02.28 |
| 申请号 |
EP19890113136 |
申请日期 |
1989.07.18 |
| 申请人 |
ZAMBON GROUP S.P.A. |
发明人 |
CAVICCHIOLI, SILVIA;PAIOCCHI, MAURIZIO;GIORDANO, CLAUDIO |
| 分类号 |
A61K31/554;C07D281/10 |
主分类号 |
A61K31/554 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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