发明名称 |
REAGENS VOOR EEN IMMUNOLOGISCHE BEPALING EN WERKWIJZE VOOR HET UITVOEREN VAN EEN DERGELIJKE BEPALING MET BEHULP VAN DIT REAGENS. |
摘要 |
Insolublized antibodies, F(ab')2 fragments thereof and protein antigens are made by coupling to a water-insoluble substrate using a bridging agent which covalently binds to sulphur atoms in antibody, fragment or protein rather than to free amino groups therein. This is preferably effected by using a chloracetyl-terminated bridging agent. Immunoassays utilizing these insolubilized reagents are described. One novel class of bridging agents comprising anhydride and monochloracetyl end groups, which is useful for making the said reagents, is also disclosed. |
申请公布号 |
NL185798(B) |
申请公布日期 |
1990.02.16 |
申请号 |
NL19790000585 |
申请日期 |
1979.01.25 |
申请人 |
TECHNICON INSTRUMENTS CORPORATION (A DELAWARE CORPORATION) TE TARRYTOWN, NEW YORK, VER. ST. V. AM. |
发明人 |
|
分类号 |
G01N33/563;A61K39/00;A61K39/44;C07D263/44;G01N33/543;G01N33/545;G01N33/547;G01N33/553;(IPC1-7):G01N33/547 |
主分类号 |
G01N33/563 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|