发明名称 |
PROCESS FOR PRODUCING A FACTOR STIMULATING THE RELEASE OF GROWTH HORMONE OF MAMMALIAN PITUITARY GLAND ORIGIN (PGRF) |
摘要 |
PGRF has been synthesized. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in mammals and which have the formula: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr- Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys- Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly- Glu-R34-Asn-Gln-Glu-R38-Gly-R40-R41-R wherein R is OH or NH2, R34 is Ser or Ala, R38 is Arg or Ser, R40 is Ala or Arg and R41 is Arg, Arg-Ala, Arg-Ala-Arg, Arg-Ala-Arg-Leu or des-R41. These peptides or biologically active fragments thereof, or analogs thereof having well-known substitutions and/or additions, as well as nontoxic salts of any of the foregoing, may be administered therapeutically to mammals, including humans, and may be used diagnostically. |
申请公布号 |
HU198952(B) |
申请公布日期 |
1989.12.28 |
申请号 |
HU19830002511 |
申请日期 |
1983.06.16 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES,US |
发明人 |
LING,NICHOLAS C.,US;ESCH,FREDERICK S.,US;BOHLEN,PETER,US;GUILLEMIN,ROGER C.,US;BRAZEAU JUN,PAUL E.,US |
分类号 |
C07K14/575;A23K1/16;A61K;A61K38/00;A61K38/04;A61P5/00;C07C;C07K14/00;C07K14/60;C07K14/61 |
主分类号 |
C07K14/575 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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