1-PIPERAZINE CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS

摘要

1-piparazinecarboxamide derivatives are described which have the formula (I)

wherein R1 is a member selected from hydrogen, halogen or trifluoromethyl;
wherein X is selected from:
> CO (Ia)
> CHOH (Ib) > CHOR8 (Ib min ) > CHOCOR8 (Ib sec )
> CH2 (Ic)
> C = CR6R7 (Id)
> CH - CHR6R7 (Ie)

wherein R2 and R3 are the same or different and selected from hydrogen or lower alkyl;
wherein Z ist either oxygen or sulfur;
wherein Y is -NR4R5, where R4 and R5 are the same or different and selected from hydrogen, alkyl, alkenyl, cycloalkyl, aryl, aryl-(lower alkyl), or R4 and R5 may together with the N-atom form a 5- or 6- or 7-membered satin red ring, where one of the carbon atoms may be exchanged for O, NR8 or NCOR8;
wherein R6 and R7 are the same or different and selected from hydrogen or lower alkyl;
wherein R8 is lower alkyl or lower alkenyl;
with the proviso that when X is > CO, then R4 is hydrogen and R5 is different from hydrogen.
Pharmaceutical compositions containing said 1-piperazinecarboxamide derivates are also described.
The derivatives are useful in treating mental disorders and/or aggression in man and in treating aggression in animals and for calming animals.
Different processes for preparing the derivatives are also described.