NOVEL CROSSLINKED CELLULOSE CHROMATOGRAPHY MEDIA

摘要

A crosslinked cellulose has been developed which retains the highly rigid structure of cellulose upon chemical derivatization in aqueous solution and at high pH and ionic strength. The method of this invention involves a cross-linking process which is carried out in organic solvents. The organic solvent crosslinking medium prevents the hydrogen bonded structure of cellulose fibers from being dissociated yielding fibers which not only retain the original compact and rigid structure of native cellulose but are superior to native cellulose in dimensional stability and swelling characteristics. The crosslinked product can be readily derivatized by ionic, hydrophobic or reactive groups and is suitable for the mobilization of proteins or other biomolecules.