Process and apparatus for making a polygonal spear and spear of this kind

摘要

The amides of cyclomethylen-1,2-bicarboxylic acids having the formula: m is 0 or 1 and n is an integer varying between 0 and 3, are endowed with ACE-inhibiting activity and are thus therapeutically useful as anti-hypertension agents. For their preparation cyclomethylene-1,2-bicarboxylic acid or a derivative thereof is condensed either with an amino derivative containing a protected hydroxamic group, or with an aminoester, and then in the former case the protecting group is removed, or in the latter case is reacted with either hydroxylamine or N-alkylhydroxylamine.