| 摘要 |
<p>NEW MATERIAL:A compound expressed by formula I and salt thereof. USE:An antimicrobial agent, having antimicrobial activity against Serratia.marcescens, bacteria of the genus Providencia and Pseudomonas.aeruginosa of 2-4times based on that of netilmicin with toxicity reduced by half. PREPARATION:A protected derivative of 5-O-acetyl-epinetilmicin expressed by formula II (Ac is acetyl; A is amino-protecting group; B is acyl group type hydroxyl-protecting group) is initially reacted with an alkaline metal alkoxide or alkaline (earth) metal hydroxide to eliminate acetyl group at the 5-position and the protecting group (B) from the compound expressed by formula II. The protecting group (A), as necessary, is then eliminated from the resultant 5- epinetilmicin derivative expressed by formula III (A, is H or A). Furthermore, the compound expressed by formula II is a novel substance and synthesized from, e.g., netilmicin expressed by formula IV, as a raw material.</p> |
