发明名称 |
INHIBITION OF INTESTINAL CHOLESTEROL AND FATTY ACID ABSORPTION |
摘要 |
Intestinal cell endogenous heparin-mediated absorption of cholesterol or fatty acids in mammals is inhibited through the oral administration of heparin, an active heparin subfraction or heparinase. Suppression of cholesterol esterase-mediated absorption in humans can be inhibited by soluble heparin by two mechanisms, i.e. displacement of the enzyme from the intestinal cell membrane and inhibition of enzymatic activity of the displaced enzyme. |
申请公布号 |
WO8908456(A1) |
申请公布日期 |
1989.09.21 |
申请号 |
WO1989US00787 |
申请日期 |
1989.02.27 |
申请人 |
THE JEWISH HOSPITAL OF ST. LOUIS |
发明人 |
LANGE, LOUIS, G., III;SPILBURG, CURTIS, A.;KINNUNEN, PAULA, M. |
分类号 |
A61K38/51;C12N9/18;(IPC1-7):A61K31/70;A61K31/715;A61K37/48;A61K31/725 |
主分类号 |
A61K38/51 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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