发明名称 |
Alteration of pharmacokinetics of proteins by charge modification. |
摘要 |
<p>There is disclosed charge-modified conjugates comprising a targeting protein bound to a therapeutic or diagnostic agent. Charge-modifying a conjugate to cause an acidic shift in the isoelectric point results in prolonged serum half-life upon in vivo administration and is useful to accumulate a therapeutic agent at the target site. Conversely, charge-modification to cause a basic shift in the isoelectric point of the conjugate reduces serum half-life upon in vivo use for diagnostic imaging purposes and results in higher target-to-background ratios.</p> |
申请公布号 |
EP0329185(A2) |
申请公布日期 |
1989.08.23 |
申请号 |
EP19890102810 |
申请日期 |
1989.02.17 |
申请人 |
NEORX CORPORATION |
发明人 |
MORGAN, ALTON C., JR.;SIVAM, GOWSALA P.;ABRAMS, PAUL G. |
分类号 |
A61K45/00;A61K38/21;A61K39/395;A61K47/48;A61K49/00;A61K51/00;A61K51/10;A61P35/00;A61P43/00;C07K1/00;C07K1/107;C07K14/00;C07K14/435;C07K14/505;C07K14/52;C07K14/53;C07K14/555;C07K14/575;C07K16/00 |
主分类号 |
A61K45/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|