发明名称 |
Carbohydrate perturbations of viruses or viral antigens and utilization for diagnostic prophylactic and/or therapeutic applications |
摘要 |
Novel and improved methods for diagnosis, prognosis, prophylaxis and therapy of viral infections are described. The novel methods employ a virus, viral antigen or fragment thereof in which "perturbation" of an oligosaccharide moiety renders the virus, viral antigen or fragment thereof more specifically recognizable or reactive with neutralizing antibody. As described, "perturbation" of an oligosaccharide moiety encompasses any modification that (1) alters the chemical or physical structure of a carbohydrate residue that is naturally present; (2) that removes, wholly or in part, a carbohydrate residue; and/or (3) that prevents or alters addition of a carbohydrate residue. A variety of methods for oligosaccharide "perpetuation" are also described.
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申请公布号 |
US4853326(A) |
申请公布日期 |
1989.08.01 |
申请号 |
US19860928631 |
申请日期 |
1986.11.18 |
申请人 |
CYTOGEN CORPORATON;INST NAT SANTE RECH MED |
发明人 |
QUASH, GERARD A.;RODWELL, JOHN D.;MCKEARN, THOMAS J.;RIPOLL, JEAN P. |
分类号 |
G01N33/543;A61K38/00;A61K39/00;A61K39/42;C07K14/005;C07K16/08;C07K16/12;C07K16/18;C12Q1/00;C12Q1/70;G01N33/547;G01N33/569 |
主分类号 |
G01N33/543 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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