摘要 |
Cardiovascular activity is exhibited by compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R1 is (1) or (2); R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, -(CH2)n-Y1, or halo substituted alkyl; R3 is hydrogen, alkyl, cycloalkyl, aryl, -(CH2)n-Y2, -(CH2)p-Y3, or halo substituted alkyl; R4 is aryl; R5 is hydrogen, alkyl, cycloalkyl, aryl, or arylalkyl and R6 is hydrogen, alkyl, cycloalkyl, -(CH2)n-Y2, -(CH2)p-Y3 or halo substituted alkyl, or R5 and R6 taken together with the nitrogen atom to which they are attached are 1-pyrrolidinyl, 1-piperidinyl, 1-azepinyl, 4-morpholinyl, 4-thiamorpholinyl, 1-piperazinyl, 4-alkyl-1-piperazinyl, 4-arylalkyl-1-piperazinyl, 4-diarylalkyl-1-piperazinyl or 1-pyrrolidinyl, 1-piperidinyl, or 1-azeipinyl substituted with alkyl, alkoxy, alkylthio, halo, trifluoromethyl or hydroxy; R7 is alkyl, cycloalkyl, aryl, -(CH2)n-Y2, -(CH2)p-Y3 or halo substituted alkyl; Y1 is cycloalkyl, aryl, hydroxyl, alkoxy, aryl-(CH2)m-O-, mercapto, alkylthio, aryl-(CH2)m-S-, amino, substituted amino, carbamoyl, (3), carboxyl, alkoxycarbonyl, (4), (5), (6) or (7); Y2 is cycloalkyl, aryl, carbamoyl, (3), carboxyl, alkoxycarbonyl, (4), or (5); Y3 is hydroxyl, alkoxy, aryl-(CH2)m-O-, mercapto, alkylthio, aryl-(CH2)m-S-, (6), (7), amino or substituted amino; m is 0 or an integer of 1 to 6; n is an integer of 1 to 6; and p is an integer of 2 to 6. |