摘要 |
The (+)-cis-, (-)-cis-, (+)-trans- and (-)-trans- forms of 2-methylspiro(1,3-oxathiolan-5,3 min )quinuclidine <CHEM> are prepared by optical resolution of each of the (+/-)-cis- and (+/-)-trans-isomers. These compounds find application in treating diseases of the central nervous system in mammals, especially diseases due to a deficiency in the central cholinergic system. Biological tests indicate that the (-)-cis-form, as well as the (+/-)-cis-isomer, shows particular promise for treating senile dementia of Alzheimer's type. |