Isoquinoline derivatives and their use

摘要

Compounds of the formula (I) <IMAGE> in which R1 is hydrogen or C1-C4-alkyl, R2 is hydrogen, and R3 is hydrogen or C1-C4-alkyl, or R2 and R3 together form a further bond, as is indicated by the dotted line, R4 is hydrogen, C1-C4-alkyl or phenyl, R5 is methoxy or ethoxy, R6 is hydrogen, hydroxyl, C1-C4-alkoxy, hydroxy-(C2-C4)-alkoxy or (C1-C4)-alkoxy-(C2-C4)-alkoxy, R7 and R8 independently of one another are C1-C4-alkoxy or (C1-C4)-alkoxy-(C2-C4)-alkoxy and R9 is hydrogen or halogen, in free form or in the form of a pharmaceutically acceptable salt; these compounds are pharmaceutically utilisable, i.e. in particular as bronchodilatory agents, as agents for inhibiting accumulation and/or activation of eosinophils and also for the treatment or prophylactic treatment of obstructive or inflammatory diseases of the airways.