| 摘要 |
5-Fluoro-2-methyl-1-(p-methylsulphinylbenzylidene)indenyl-3-acetic acid or its salts are prepared. The said acid is obtained by condensing 5-fluoro-2-methyl-1-R1-benzylindene, where R1 is p-methylthio or p-methylsulphinyl, with glyoxylic acid, its salt or ester to give the corresponding 5-fluoro-2-methyl-1-(p-methylthio- (or methylsulphinyl)benzyl)indenylidene-3-acetic acid, its salt or ester. If R1 is p-methylsulphinyl, the indenylidene compound is isomerised to indenyl-3-acetic acid. If R1 denotes methylthio, then the resulting indenylidene-3-acetic acid is isomerised to 5-fluoro-2-methyl-1-(p-methylthiobenzylidene)indenyl-3-acetic acid and the p-methylthio radical is then oxidised to the p-methylsulphinyl group. However, the oxidation can also be carried out first and the isomerisation subsequently. The said compounds can be used as active agents in anti-inflammatory medicaments. |
