NOVEL TETRAHYDROPYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME

摘要

The invention relates to novel tetrahydropyridine derivatives of formula (I) and pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In formula (I), R1 means hydrogen or a C1-6 alkyl group; R2 and R3 stand, independently from each other, for hydrogen or a C1-6 alkyl group; or alternatively R2 and R3 together represent a chemical bond; R4 means halogen, a trifluoromethyl or a C1-6 alkyl group; R1 and R3 are in Z (cis) or E (trans) position in their mutual relation when R2 and R3 do not form together a chemical bond or the meaning of R1 is different from that of R2, with the proviso that R1 and R2 are different from hydrogen when R4 means a 4-methyl group. The compounds of formula (I) show a strong cytoprotective action on the gastric mucosa by inhibiting the gastric acid secretion and are useful antiulcer agents.