| 摘要 |
<p>The present application relates to 4,8-dihydro-8-arylisoxazolo[4,3-e][1,4]oxazepin-5(6H)-ones of the formula I <CHEM> wherein R<1> is hydrogen, loweralkyl, arylloweralkyl, aryloxyloweralkyl, cycloalkylloweralkyl, aminoloweralkyl, loweralkylaminoloweralkyl, diloweralkylaminoloweralkyl, and loweralkoxycarbonylloweralkyl; R<2> is hydrogen or loweralkyl; Y is independently loweralkyl, loweralkoxy, halogen, trifluoromethyl or nitro; and n is an integer having a value from 0 to 2, inclusive; the geometrical isomers; optical antipodes, and pharmaceutically acceptable acid addition salts thereof. The compounds of the formula I have antihypertensive activity and can, therefore, be used as medicaments.</p> |
