发明名称 |
NOVEL TETRAPEPTIDE RENNIN INHIBITOR HAVING C-TERMINAL AMINO ACID AMIDE COMPONENT |
摘要 |
Tetrapeptides enzyme inhibitors of the formula: <CHEM> and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems employing the novel tetrapeptides. |
申请公布号 |
JPH01143899(A) |
申请公布日期 |
1989.06.06 |
申请号 |
JP19880256061 |
申请日期 |
1988.10.13 |
申请人 |
MERCK & CO INC |
发明人 |
PURASAN KEE CHIYAKURABUAATEI;UIRIAMU ETSUCHI PAASONZU;UIRIAMU JIEE GURIINRII;UIRIAMU SHIEEN |
分类号 |
A61K38/55;A61P9/00;A61P9/12;C07K5/02;C07K5/06;C07K14/81;C12N9/99 |
主分类号 |
A61K38/55 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|