| 摘要 |
Peptide compositions comprising a sequence of human CD4 which includes at least a core sequence of seven consecutive amino acids including the cysteine at position 86 (C-86) are provided. The sulfur atom of C-86 may be derivatized, and at least one amino acid other than C-86 is derivatized, generally the glutamic acid at position 87 (E-87). Various groups may be used as derivatizing groups, including aryl-containing substituents, or in the case of cysteine, a thioether resulting from the reaction between the thio group of the cysteine and a maleimide. The resulting compositions may be used prophylactically or therapeutically for inhibiting interactions between CD4 and retroviral proteins. |
