CANCER CHEMOTHERAPEUTIC CYCLIC AND ACYCLIC DISULFONIC ESTER COMPOUNDS, METHOD OF USE THEREFOR, AND INTERMEDIATES

摘要

Cyclic disulfonic ester bifunctional cross-linking compounds effective in treating certain types of cancers are described. Initial nucleophilic reaction with the compound produces a negatively charged sulfonic acid end-group which remains attached to the compound until the second nucleophilic crosslinking reaction occurs.