PROCESS FOR PREPARING ANTI-INFLAMMATORY CYCLOALKYLIDENEMETHYLPHENYLACETIC ACID DERIVATIVES

摘要

Cycloalkylidenemethylphenylacetic acid derivatives of formula (I): (I) (wherein R1 represents hydrogen or alkyl and n is an integer from 1 to 3) are prepared by reacting a benzaldehyde acid compound of formula (II): (II) with an enamine derivative of formula (III): (III) (wherein R2 and R3 are various organic groups) and then hydrolizing the product. The use of the acid of formula (II) rather than its corresponding ester enables the reaction to be effected with a good yield and under moderate and economical reaction conditions.