Method of preparing a polymeric latex composition.

摘要

A polymeric latex composition having a hydrophobe incorporated therein can be prepared using a novel method for incorporating the hydrophobe into the latex particles. This method includes providing a loadable latex, providing a hydrophobe dissolved in a water-miscible organic solvent, heating the loadable latex to 30 to 90 DEG C and gradually adding the hydrophobe solution to the heated loadable latex under conditions to keep the hydrophobe in solution and to "load" or incorporate it into the latex particles. The latex can be surfactant-free and have particles which have outer reactive groups which are capable of reacting with free amine or sulfhydryl groups of a biological compound. Such latices can be used to prepare water-insoluble biological reagents having a biological compound attached to the particles.