PHARMACEUTICAL COMPOSITIONS

摘要

PCT No. PCT/GB88/00350 Sec. 371 Date Jan. 4, 1989 Sec. 102(e) Date Jan. 4, 1989 PCT Filed May 4, 1988 PCT Pub. No. WO88/08704 PCT Pub. Date Nov. 17, 1988.The invention provides a solid pharmaceutical dosage form comprising: (i) cimetidine; and (ii) antacid, wherein at least part of the antacid is in the form of granules comprising a freely water-soluble solid diluent, the antacid, and a rapidly swellable water-insoluble disintegrant. Compositions of this type overcome the problem of the reduced bioavailability of cimetidine which can occur when cimetidine is co-administered with antacids.